Genetics

A variety of genes have been implicated in the cause of myoclonus, particularly those cases that include myoclonus as one feature of a disorder.

Myoclonus dystonia

• 7q21—DYT11, SCGE
• 18p11—DYT15

Myoclonic epilepsy

• 8q24—Familial adult myoclonic epilepsy
• G8363A mutation—MERRF
• 21q22.3—CSTB gene—Unverricht-Lundborg disease
• 6p24—EPM2A, EPM2B—Lafora progressive myoclonic epilepsy

Other

• PRNP H187R—Hereditary Creutzfeldt-Jakob disease
• 3242A>G—MELAS
• 22q11—DiGeorge syndrome

	Epidemiology